Future directions and research priorities for food mutagens*

Past, present, and future of mutagens in cooked foods.

Mutation assay with Salmonella typhimurium enabled us to detect various types of mutagens in cooked foods. A series of mutagenic heterocyclic amines has been isolated and identified in broiled fish and meat and in pyrolyzates of amino acids and proteins. Feeding experiments showed these mutagens to be carcinogenic in mice and rats. The mechanism of formation and pathway of metabolic activation ...

Chemistry of Maillard reactions: recent studies on the browning reaction mechanism and the development of antioxidants and mutagens.

Future research directions to characterize environmental mutagens in highly polluted area.

Population monitoring using methods of molecular epidemiology combined with reliable data on exposure is an extremely powerful approach to determine the effect of mutagens on human populations. Although human blood and urine have traditionally been used for biomonitoring, an increase in the use of placental and buccal smear samples should be expected. As biomarkers of exposure, DNA strand break...

Identifying emerging priorities in Knowledge Translation from the perspective of trainees

Background As the Knowledge Translation (KT) field advances, there is an increasing need to identify priorities to help shape future directions for research. An important source of KT priorities is ‘experts’ who are well-established researchers and practitioners. Another potential source for identifying priorities is trainees. Given that many KT trainees are developing their programs of researc...

The Future of Disease Control Priorities; Comment on “Disease Control Priorities Third Edition Is Published: A Theory of Change Is Needed for Translating Evidence to Health Policy”

The Disease Control Priorities (DCP) project has substantially influenced national and global health priorities since 1993. DCP’s basic framework involves identification of disease burdens based on premature deaths and disability and application of the most cost-effective interventions to the largest burdens, taking into account local feasibility. The future impact of DCP will need to take into...